Phenol Oxidation of Isoquinoline Alkaloids. III. Oixdative Coupling of dl-4'-O-Methyl-N-methylcoclaurine
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چکیده
منابع مشابه
Presence of isoquinoline alkaloids in molluscan ganglia.
UNLABELLED Tetrahydropapaveroline and reticuline, isoquinoline alkaloids, were purified and identified in the pedal ganglia of the marine mollusk Mytilus edulis. OBJECTIVES To determine the presence of tetrahydropapaveroline and reticuline, isoquinoline alkaloids, in animal tissues previously shown to express opiate receptors. METHODS AND RESULTS This was achieved by high performance liquid...
متن کاملSynthesis of isoquinoline and yohimbinoid alkaloids
A systematic survey of the different synthetic methodologies available for the syntheses of isoquinoline and yohimbinoid alkaloids revealed that the general approaches to these compounds involved either an A/B C — D/—i E approach or a D/E — C/B/A approach% We have now devised a novel method for the syntheses of both the isoquinoline and indole alkaloids belonging to the tetra— hydroprotoberberi...
متن کامل(N→B)-4-Methyl-3-pyridyl[N-methyliminodiacetate-O,O′,N]borane
The title compound, C(11)H(13)BN(2)O(4), has a rigid bicyclic structure due to an intra-molecular nitro-gen-boron dative bond. The B atom is in a distorted tetra-hedron environment with a B-N bond length of 1.640 (2) Å, which is in good comparison with the values in analogues compounds. In the crystal, the mol-ecules are linked by weak C-H⋯O and C-H⋯N inter-actions, forming a three-dimensional ...
متن کاملImprovement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants.
Coptis japonica (Cj) rhizomes are used as a crude drug for gastroenteritis, since they accumulate antimicrobial berberine. Berberine also shows various useful bioactivities, including cholesterol-lowering activity. Unfortunately, Cj is a slow-growing plant and more than 5 years are required to obtain a crude drug suitable for the Japanese Pharmacopoeia. To improve alkaloid productivity, we over...
متن کاملProtoberberine isoquinoline alkaloids from Arcangelisia gusanlung.
HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 2-15, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basi...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1968
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.16.688